GRIN2C Antibody (PACO48950)
- SKU:
- PACO48950
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | GRIN2C Antibody (PACO48950) |
抗体コード: | PACO48950 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Glutamate receptor ionotropic, NMDA 2C protein (908-1007AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO48950 at dilution of 1:100. | |
Immunofluorescent analysis of A549 cells using PACO48950 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. |
シノニム: | Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C), GRIN2C, NMDAR2C |
UniProt Protein Function: | NMDAR2C: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated Chromosomal Location of Human Ortholog: 17q25.1 Cellular Component: postsynaptic membrane; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex Molecular Function:protein binding; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein N-terminus binding; cation channel activity; PDZ domain binding Biological Process: synaptic transmission; synaptic transmission, glutamatergic; protein localization; transport; directional locomotion; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; response to wounding; regulation of excitatory postsynaptic membrane potential; neuromuscular process controlling balance; negative regulation of protein catabolic process |
NCBI Summary: | This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] |
UniProt Code: | Q14957 |
NCBI GenInfo Identifier: | 55770854 |
NCBI Gene ID: | 2905 |
NCBI Accession: | NP_000826.2 |
UniProt Secondary Accession: | Q14957,B2RTT1, |
UniProt Related Accession: | Q14957 |
Molecular Weight: | 134,209 Da |
NCBI Full Name: | glutamate receptor ionotropic, NMDA 2C isoform 1 |
NCBI Synonym Full Names: | glutamate receptor, ionotropic, N-methyl D-aspartate 2C |
NCBI Official Symbol: | GRIN2C |
NCBI Official Synonym Symbols: | NR2C; GluN2C; NMDAR2C |
NCBI Protein Information: | glutamate receptor ionotropic, NMDA 2C; N-methyl D-aspartate receptor subtype 2C; N-methyl-D-aspartate receptor subunit 2C; glutamate [NMDA] receptor subunit epsilon-3 |
UniProt Protein Name: | Glutamate receptor ionotropic, NMDA 2C |
UniProt Synonym Protein Names: | Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C |
Protein Family: | Glutamate receptor ionotropic |
UniProt Gene Name: | GRIN2C |
UniProt Entry Name: | NMDE3_HUMAN |