FBXO3 Antibody, HRP conjugated (PACO51199)
- SKU:
- PACO51199
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | FBXO3 Antibody, HRP conjugated (PACO51199) |
抗体コード: | PACO51199 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human F-box only protein 3 protein (276-376AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. |
シノニム: | F-box only protein 3, FBXO3, FBX3 |
UniProt Protein Function: | Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Ref.6 |
UniProt Protein Details: | Subunit structure: Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex. Ref.6 Subcellular location: Nucleus. Note: Colocalizes with PML at the peripheries of nuclear bodies. Sequence similarities: Contains 1 apaG domain.Contains 1 F-box domain. |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UK99 |
NCBI GenInfo Identifier: | 71297179 |
NCBI Gene ID: | 26273 |
NCBI Accession: | AAH39291.1 |
UniProt Secondary Accession: | Q9UK99,Q86X90, Q9H0V2, Q9NUX2, B3KY16, D3DR05, |
UniProt Related Accession: | Q9UK99 |
Molecular Weight: | 54,561 Da |
NCBI Full Name: | FBXO3 protein |
NCBI Synonym Full Names: | F-box protein 3 |
NCBI Official Symbol: | FBXO3 |
NCBI Official Synonym Symbols: | FBA; FBX3 |
NCBI Protein Information: | F-box only protein 3; F-box protein FBX3 |
UniProt Protein Name: | F-box only protein 3 |
Protein Family: | F-box only protein |
UniProt Gene Name: | FBXO3 |
UniProt Entry Name: | FBX3_HUMAN |