CLIC4 Antibody (PACO19484)
- SKU:
- PACO19484
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| 抗体名: | CLIC4 Antibody (PACO19484) |
| 抗体コード: | PACO19484 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Synthetic peptide of human CLIC4 |
| 憲法: | Liquid |
| ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 精製方法: | Antigen affinity purification |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE,Lysate: 40 μg,Lane 1-2: Human normal kidney tissue, Human liver tissue,Primary antibody: PACO19484(CLIC4 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds. |
| バックグラウンド: | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). |
| シノニム: | chloride intracellular channel 4 |
| UniProt Protein Function: | CLIC4: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Belongs to the chloride channel CLIC family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: centrosome; cell surface; nuclear matrix; microvillus; cytoplasmic vesicle membrane; mitochondrion; intercellular junction; cytosol; actin cytoskeleton; microtubule cytoskeleton; apical part of cell; perinuclear region of cytoplasm; cytoplasm; plasma membrane; intracellular; midbody Molecular Function:chloride channel activity; protein binding; voltage-gated ion channel activity Biological Process: keratinocyte differentiation; vacuolar acidification; fertilization; branching morphogenesis of a tube; apoptosis; multicellular organism growth; establishment and/or maintenance of apical/basal cell polarity; chloride transport; angiogenesis; endothelial cell morphogenesis; cell differentiation; negative regulation of cell migration; regulation of cytoskeleton organization and biogenesis |
| NCBI Summary: | Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y696 |
| NCBI GenInfo Identifier: | 20141285 |
| NCBI Gene ID: | 25932 |
| NCBI Accession: | Q9Y696.4 |
| UniProt Secondary Accession: | Q9Y696,Q9UFW9, Q9UQJ6, |
| UniProt Related Accession: | Q9Y696 |
| Molecular Weight: | 253 |
| NCBI Full Name: | Chloride intracellular channel protein 4 |
| NCBI Synonym Full Names: | chloride intracellular channel 4 |
| NCBI Official Symbol: | CLIC4 |
| NCBI Official Synonym Symbols: | H1; huH1; p64H1; CLIC4L; MTCLIC |
| NCBI Protein Information: | chloride intracellular channel protein 4; chloride intracellular channel 4 like; intracellular chloride ion channel protein p64H1 |
| UniProt Protein Name: | Chloride intracellular channel protein 4 |
| UniProt Synonym Protein Names: | Intracellular chloride ion channel protein p64H1 |
| Protein Family: | Chloride intracellular channel protein |
| UniProt Gene Name: | CLIC4 |
| UniProt Entry Name: | CLIC4_HUMAN |