Anti-SSRP1 Antibody (CAB13636)
- SKU:
- CAB13636
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-SSRP1 Antibody |
| 抗体コード: | CAB13636 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SSRP1 (NP_003137.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | SW620, HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SSRP1 (NP_003137.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAET LEFN DVYQ EVKG SMND GRLR LSRQ GIIF KNSK TGKV DNIQ AGEL TEGI WRRV ALGH GLKL LTKN GHVY KYDG FRES EFEK LSDF FKTH YRLE LMEK DLCV KGWN WGTV KFGG QLLS FDIG DQPV FEIP LSNV SQCT TGKN EVTL EFHQ NDDA EVSL MEVR FYVP PTQE DGVD PVEA FAQN VLSK ADVI QATG DAIC IFRE LQCL TPRG RYDI RIYP TFLH LHGK TFDY KIPY TTVL RLFL LPHK DQRQ MFFV ISLD PPIK QGQT RYHF LILL FSKD EDIS LTLN MNEE EVEK RFEG |
| 遺伝子ID: | 6749 |
| Uniprot: | Q08945 |
| セルラーロケーション: | Chromosome, Nucleus, nucleolus |
| 計算された分子量: | 81kDa |
| 観察された分子量: | 85kDa |
| 同義語: | SSRP1, FACT, FACT80, T160 |
| バックグラウンド: | The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. |
| UniProt Protein Function: | SSRP1: a subunit of the chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. |
| UniProt Protein Details: | Protein type:RNA-binding; Nucleolus; Transcription initiation complex; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 11q12 Cellular Component: cytoplasm; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter |
| NCBI Summary: | The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08945 |
| NCBI GenInfo Identifier: | 730840 |
| NCBI Gene ID: | 6749 |
| NCBI Accession: | Q08945.1 |
| UniProt Secondary Accession: | Q08945,Q5BJG8, |
| UniProt Related Accession: | Q08945 |
| Molecular Weight: | 81,075 Da |
| NCBI Full Name: | FACT complex subunit SSRP1 |
| NCBI Synonym Full Names: | structure specific recognition protein 1 |
| NCBI Official Symbol: | SSRP1 |
| NCBI Official Synonym Symbols: | FACT; T160; FACT80 |
| NCBI Protein Information: | FACT complex subunit SSRP1 |
| UniProt Protein Name: | FACT complex subunit SSRP1 |
| UniProt Synonym Protein Names: | Chromatin-specific transcription elongation factor 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; FACT 80 kDa subunit; FACTp80; Facilitates chromatin transcription complex subunit SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; hSSRP1; T160 |
| UniProt Gene Name: | SSRP1 |
| UniProt Entry Name: | SSRP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SSRP1 antibody (CAB13636) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human esophageal cancer using SSRP1 antibody (CAB13636) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using SSRP1 antibody (CAB13636). |
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