Anti-RHO Antibody (CAB15093)
- SKU:
- CAB15093
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-RHO Antibody |
| 抗体コード: | CAB15093 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human RHO (NP_000530.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | mouse eye, rat eye |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human RHO (NP_000530.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NESF VIYM FVVH FTIP MIII FFCY GQLV FTVK EAAA QQQE SATT QKAE KEVT RMVI IMVI AFLI CWVP YASV AFYI FTHQ GSNF GPIF MTIP AFFA KSAA IYNP VIYI MMNK QFRN CMLT TICC GKNP LGDD EASA TVSK TETS QVAP A |
| 遺伝子ID: | 6010 |
| Uniprot: | P08100 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 38kDa |
| 観察された分子量: | 39kDa |
| 同義語: | RHO, CSNBAD1, OPN2, RP4, rhodopsin |
| バックグラウンド: | Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form, which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. |
| UniProt Protein Function: | Rhodopsin: a G-protein coupled receptor. The light-absorbing visual pigment in Rod photoreceptor cells. Mediates vision in dim light. Consists of the apoprotein, opsin, covalently linked to cis-retinal. Defects in RHO are a cause of autosomal retinitis pigmentosa and congenital stationary night blindness. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 3q21-q24 Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; photoreceptor inner segment; photoreceptor outer segment; plasma membrane Molecular Function:G-protein coupled photoreceptor activity; G-protein coupled receptor activity; protein binding Biological Process: absorption of visible light; G-protein coupled receptor protein signaling pathway; phototransduction, visible light; regulation of rhodopsin mediated signaling; retinoid metabolic process; rhodopsin mediated signaling Disease: Fundus Albipunctatus; Night Blindness, Congenital Stationary, Autosomal Dominant 1; Retinitis Pigmentosa 4 |
| NCBI Summary: | Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08100 |
| NCBI GenInfo Identifier: | 129207 |
| NCBI Gene ID: | 6010 |
| NCBI Accession: | P08100.1 |
| UniProt Secondary Accession: | P08100,Q16414, Q2M249, |
| UniProt Related Accession: | P08100 |
| Molecular Weight: | 38,893 Da |
| NCBI Full Name: | Rhodopsin |
| NCBI Synonym Full Names: | rhodopsin |
| NCBI Official Symbol: | RHO |
| NCBI Official Synonym Symbols: | RP4; OPN2; CSNBAD1 |
| NCBI Protein Information: | rhodopsin |
| UniProt Protein Name: | Rhodopsin |
| UniProt Synonym Protein Names: | Opsin-2 |
| Protein Family: | Rhotekin |
| UniProt Gene Name: | RHO |
| UniProt Entry Name: | OPSD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RHO antibody (CAB15093) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded mouse retina using RHO antibody (CAB15093) at dilution of 1:200 (40x lens). |
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