UniProt Protein Function: | VTCN1: Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor- associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p13.1-p12 |
NCBI Summary: | This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
UniProt Code: | Q7Z7D3 |
NCBI GenInfo Identifier: | 74759262 |
NCBI Gene ID: | 79679 |
NCBI Accession: | Q7Z7D3.1 |
UniProt Secondary Accession: | Q7Z7D3,Q0GN76, Q45VN0, Q5WPZ3, Q6P097, Q9H6B2, |
UniProt Related Accession: | Q7Z7D3 |
Molecular Weight: | |
NCBI Full Name: | V-set domain-containing T-cell activation inhibitor 1 |
NCBI Synonym Full Names: | V-set domain containing T-cell activation inhibitor 1 |
NCBI Official Symbol: | VTCN1 |
NCBI Official Synonym Symbols: | B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291 |
NCBI Protein Information: | V-set domain-containing T-cell activation inhibitor 1 |
UniProt Protein Name: | V-set domain-containing T-cell activation inhibitor 1 |
UniProt Synonym Protein Names: | B7 homolog 4; B7-H4; B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x |
UniProt Gene Name: | VTCN1 |