LRRK1 Antibody (PACO05373)
- SKU:
- PACO05373
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | LRRK1 Antibody (PACO05373) |
抗体コード: | PACO05373 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:5000, IHC:1:100-1:300, IF:1:200-1:1000 |
反応性: | Human |
免疫原: | Synthesized peptide derived from the Internal region of human LRRK1. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | LRRK1; KIAA1790; Leucine-rich repeat serine/threonine-protein kinase 1 |
UniProt Protein Function: | LRRK1: a large multidomain protein kinase with a TKL-type kinase domain, multiple protein-protein interaction domains and a mitochondrial Rho domain (MIRO). Involved in the trafficking of epidermal growth factor (EGFR) from early to late endosomes. Forms a complex with activated EGFR via the adaptor protein Grb2. Subsequently, LRRK1 and EGFR are internalized and co-localized in early endosomes. LRRK1 is phosphorylated by EGFR, inhibiting its kinase activity. The reduction of kinase activity plays an important role in endosomal trafficking of the EGFR. Serves as a scaffold expediting the interaction of EGFR with the endosomal sorting complex required for efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Plays a critical role in negative regulation of bone mass in part through modulating the c-Src signaling pathway in mice. Phosphorylation of c-Src at Tyr-527 is significantly elevated whereas at Tyr-416 is decreased in LRRK1 KO mouse osteoclasts. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; TKL group; LRRK family Chromosomal Location of Human Ortholog: 15q26.3 Cellular Component: cytoplasm; mitochondrion Molecular Function:identical protein binding; protein binding |
UniProt Code: | Q38SD2 |
NCBI GenInfo Identifier: | 313104220 |
NCBI Gene ID: | 79705 |
NCBI Accession: | Q38SD2.3 |
UniProt Secondary Accession: | Q38SD2,Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3 |
UniProt Related Accession: | Q38SD2 |
Molecular Weight: | 28,848 Da |
NCBI Full Name: | Leucine-rich repeat serine/threonine-protein kinase 1 |
NCBI Synonym Full Names: | leucine rich repeat kinase 1 |
NCBI Official Symbol: | LRRK1 |
NCBI Official Synonym Symbols: | RIPK6; Roco1 |
NCBI Protein Information: | leucine-rich repeat serine/threonine-protein kinase 1 |
UniProt Protein Name: | Leucine-rich repeat serine/threonine-protein kinase 1 |
Protein Family: | Leucine-rich repeat serine/threonine-protein kinase |
UniProt Gene Name: | LRRK1 |
UniProt Entry Name: | LRRK1_HUMAN |