KCNMB2 Antibody (PACO22214)
- SKU:
- PACO22214
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | KCNMB2 Antibody (PACO22214) |
抗体コード: | PACO22214 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from internal of human KCNMB2. |
憲法: | Liquid |
ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from HepG2 cells, COLO cells and Jurkat cells, using KCNMB2 antibody. |
バックグラウンド: | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. |
シノニム: | BK channel beta-2; BKbeta2; calcium-activated potassium channel beta-2; calcium-activated potassium channel; subfamily M beta-2 |
UniProt Protein Function: | KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q26.32 Cellular Component: integral to plasma membrane; plasma membrane; voltage-gated potassium channel complex Molecular Function:calcium-activated potassium channel activity; ion channel inhibitor activity; potassium channel regulator activity Biological Process: detection of calcium ion; generation of action potential; potassium ion transport; regulation of action potential; regulation of vasoconstriction; synaptic transmission |
NCBI Summary: | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9Y691 |
NCBI GenInfo Identifier: | 46396054 |
NCBI Gene ID: | 10242 |
NCBI Accession: | Q9Y691.1 |
UniProt Related Accession: | Q9Y691 |
Molecular Weight: | 27kDa |
NCBI Full Name: | Calcium-activated potassium channel subunit beta-2 |
NCBI Synonym Full Names: | potassium calcium-activated channel subfamily M regulatory beta subunit 2 |
NCBI Official Symbol: | KCNMB2 |
NCBI Protein Information: | calcium-activated potassium channel subunit beta-2 |
UniProt Protein Name: | Calcium-activated potassium channel subunit beta-2 |
UniProt Synonym Protein Names: | BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2 |
Protein Family: | Calcium-activated potassium channel |
UniProt Gene Name: | KCNMB2 |