Anti-VAV2 Antibody (CAB9483)

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SKU:
CAB9483
Product type:
Antibody
Application:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cardiovascular
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Description

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抗体名:Anti-VAV2 Antibody
抗体コード:CAB9483
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 570-700 of human VAV2 (NP_001127870.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:U-87MG, 293T, HeLa, HepG2, Mouse liver, Mouse lung, Mouse spleen, Rat kidney
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 570-700 of human VAV2 (NP_001127870.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:PPCK FTSP ADLD ASGA GPGP KMVA MQNY HGNP APPG KPVL TFQT GDVL ELLR GDPE SPWW EGRL VQTR KSGY FPSS SVKP CPVD GRPP ISRP PSRE IDYT AYPW FAGN MERQ QTDN LLKS HASG TYLI RER
遺伝子ID:7410
Uniprot:P52735
セルラーロケーション:
計算された分子量:97kDa/100kDa/101kDa
観察された分子量:101kDa
同義語:VAV2, VAV-2
バックグラウンド:VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:VAV2: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues.
UniProt Protein Details:

Protein type:GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.2

Cellular Component: cytosol

Molecular Function:guanyl-nucleotide exchange factor activity; protein binding; Rho guanyl-nucleotide exchange factor activity

Biological Process: ephrin receptor signaling pathway; platelet activation; positive regulation of apoptosis; regulation of blood coagulation; regulation of cell size; regulation of gene expression; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; vascular endothelial growth factor receptor signaling pathway

NCBI Summary:VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Code:P52735
NCBI GenInfo Identifier:212287930
NCBI Gene ID:7410
NCBI Accession:P52735.2
UniProt Secondary Accession:P52735,Q5SYV3, Q5SYV4, Q5SYV5, Q6N012, Q6PIJ9, Q6Q317 A2RUM4, A8MQ12, B6ZDF5,
UniProt Related Accession:P52735
Molecular Weight:97,032 Da
NCBI Full Name:Guanine nucleotide exchange factor VAV2
NCBI Synonym Full Names:vav guanine nucleotide exchange factor 2
NCBI Official Symbol:VAV2  
NCBI Official Synonym Symbols:VAV-2  
NCBI Protein Information:guanine nucleotide exchange factor VAV2
UniProt Protein Name:Guanine nucleotide exchange factor VAV2
Protein Family:Guanine nucleotide exchange factor
UniProt Gene Name:VAV2  
Anti-VAV2 Polyclonal Antibody (CAB9483)Western blot analysis of extracts of various cell lines, using VAV2 antibody (CAB9483) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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