Anti-SLC6A2 抗体 (CAB1421)

抗体名:	Anti-SLC6A2 Antibody
抗体コード:	CAB1421
抗体サイズ:	20uL, 50uL, 100uL
申し込み:	WB
反応性:	Human, Mouse, Rat
宿主種:	Rabbit
免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC6A2 (NP_001165975.1).

申し込み:	WB
推奨希釈:	WB 1:500 - 1:2000
反応性:	Human, Mouse, Rat
ポジティブサンプル:	A-549, SH-SY5Y, Mouse kidney, Mouse spinal cord

免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human SLC6A2 (NP_001165975.1).
精製方法:	Affinity purification
ストレージバッファ:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:	IgG
順序:	MLLA RMNP QVQP ENNG ADTG PEQP LRAR KTAE LLVV KERN GVQC LLAP RDGD AQPR ETWG KKID FLLS VV
遺伝子ID:	6530
Uniprot:	P23975
セルラーロケーション:	Membrane, Multi-pass membrane protein
計算された分子量:	57kDa/69kDa/70kDa
観察された分子量:	69kDa

同義語:

SLC6A2, NAT1, NET, NET1, SLC6A5

バックグラウンド:

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

UniProt Protein Function:	SLC6A2: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A2 are a cause of orthostatic intolerance (OI). OI is a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily.
UniProt Protein Details:	Protein type:Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 16q12.2 Cellular Component: integral to plasma membrane; membrane; neuron projection; plasma membrane Molecular Function:dopamine:sodium symporter activity; metal ion binding; monoamine transmembrane transporter activity; norephinephrine:sodium symporter activity; protein binding Biological Process: dopamine uptake; monoamine transport; norepinephrine transport; response to pain; synaptic transmission; transmembrane transport; transport Disease: Orthostatic Intolerance
NCBI Summary:	This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
UniProt Code:	P23975
NCBI GenInfo Identifier:	128616
NCBI Gene ID:	6530
NCBI Accession:	P23975.1
UniProt Secondary Accession:	P23975,Q96KH8, B2R707, B4DX48,
UniProt Related Accession:	P23975
Molecular Weight:
NCBI Full Name:	Sodium-dependent noradrenaline transporter
NCBI Synonym Full Names:	solute carrier family 6 member 2
NCBI Official Symbol:	SLC6A2
NCBI Official Synonym Symbols:	NET; NAT1; NET1; SLC6A5
NCBI Protein Information:	sodium-dependent noradrenaline transporter
UniProt Protein Name:	Sodium-dependent noradrenaline transporter
UniProt Synonym Protein Names:	Norepinephrine transporter; NET; Solute carrier family 6 member 2
Protein Family:	Sodium-dependent noradrenaline transporter
UniProt Gene Name:	SLC6A2
UniProt Entry Name:	SC6A2_HUMAN

Western blot analysis of extracts of various cell lines, using SLC6A2 antibody (CAB1421) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

ELISA Kits

Human Sodium-dependent noradrenaline transporter (SLC6A2) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)