Anti-Phospho-TAK1-T184/T187 Antibody (CABP1227)
- SKU:
- CABP1227
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CSCF
- Synonyms:
- FMD2
- Synonyms:
- MEKK7
- Synonyms:
- TAK1
- Synonyms:
- TGF1a
- Synonyms:
- MAP3K7
Description
| 抗体名: | Phospho-TAK1-T184/T187 Rabbit pAb |
| 抗体コード: | CABP1227 |
| サイズ: | 50uL, 100uL |
| 同義語: | CSCF, FMD2, MEKK7, TAK1, TGF1a, MAP3K7 |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic phosphorylated peptide around T184 & T187 of human TAK1 (NP_003179.1). |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T |
| 免疫原: | A synthetic phosphorylated peptide around T184 & T187 of human TAK1 (NP_003179.1). |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 6885 |
| Uniprot: | O43318 |
| 計算された分子量: | 53kDa/56kDa/64kDa/67kDa |
| 観察された分子量: | 82kDa |
| UniProt Protein Function: | TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TKL; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; TAK1 subfamily Chromosomal Location of Human Ortholog: 6q15 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; endosome membrane; IkappaB kinase complex; nucleus; cytosol Molecular Function:MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK activity; activation of MAPKK activity; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of T cell cytokine production; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; JNK cascade; angiogenesis; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of T cell activation; I-kappaB phosphorylation; neural tube formation |
| NCBI Summary: | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43318 |
| NCBI GenInfo Identifier: | 12643557 |
| NCBI Gene ID: | 6885 |
| NCBI Accession: | O43318.1 |
| UniProt Secondary Accession: | O43318,O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7, Q9NTR3 Q9NZ70, B2RE27, E1P523, |
| UniProt Related Accession: | O43318 |
| Molecular Weight: | 67,196 Da |
| NCBI Full Name: | Mitogen-activated protein kinase kinase kinase 7 |
| NCBI Synonym Full Names: | mitogen-activated protein kinase kinase kinase 7 |
| NCBI Official Symbol: | MAP3K7 |
| NCBI Official Synonym Symbols: | TAK1; MEKK7; TGF1a |
| NCBI Protein Information: | mitogen-activated protein kinase kinase kinase 7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1 |
| UniProt Protein Name: | Mitogen-activated protein kinase kinase kinase 7 |
| UniProt Synonym Protein Names: | Transforming growth factor-beta-activated kinase 1 |
| Protein Family: | Mitogen-activated protein kinase kinase kinase |
| UniProt Gene Name: | MAP3K7 |
| UniProt Entry Name: | M3K7_HUMAN |
Related Products
Anti-Phospho-TAK1-T187 Antibody (CABP1222)
Anti-Phospho-CDKN1B-T187 Antibody (CABP0328)
Anti-Phospho-MAP3K7-T187 pAb Antibody (CABP0811)
