Anti-Phospho-PLCG2-Y759 pAb Antibody (CABP0785)

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SKU:
CABP0785
Product type:
Antibody
Application:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
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Description

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抗体名:Anti-Phospho-PLCG2-Y759 Antibody
抗体コード:CABP0785
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:A synthetic phosphorylated peptide around Y759 of human PLCG2 (NP_002652.2).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:Raji
免疫原:A synthetic phosphorylated peptide around Y759 of human PLCG2 (NP_002652.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:RMYV D
遺伝子ID:5336
Uniprot:P16885
セルラーロケーション:
計算された分子量:147kDa
観察された分子量:150kDa
Anti-Phospho-PLCG2-Y759 pAb (CABP0785)Western blot analysis of extracts of Raji cells, using Phospho-PLCG2-Y759 antibody (CABP0785) at 1:2000 dilution or PLCG2 antibody (CAB2182). Raji cells were treated by Pervanadate (1 mM) at 37'C for 30 minutes. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-Phospho-PLCG2-Y759 pAb (CABP0785)Western blot analysis of extracts of Raji cells, using Anti-Phospho-PLCG2-Y759 pAb (CABP0785) at 1:2000 dilution or PLCG2 antibody (CAB2182).Raji cells were treated by Pervanadate (1 mM) at 37'C for 30 minutes. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
同義語:PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2
バックグラウンド:The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4, 5-bisphosphate to 1D-myo-inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3.
UniProt Protein Function:PLCG2: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. It is a crucial enzyme in transmembrane signaling. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - inositol phosphate; Phospholipase; EC 3.1.4.11; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16q24.1

Cellular Component: plasma membrane; cytosol

Molecular Function:signal transducer activity; protein binding; phospholipase C activity; phosphoinositide phospholipase C activity

Biological Process: platelet activation; Wnt receptor signaling pathway; inositol phosphate metabolic process; phospholipid catabolic process; calcium-mediated signaling; response to lipopolysaccharide; T cell receptor signaling pathway; activation of store-operated calcium channel activity; B cell receptor signaling pathway; regulation of gene expression; inositol trisphosphate biosynthetic process; B cell differentiation; release of sequestered calcium ion into cytosol; negative regulation of programmed cell death; phosphatidylinositol biosynthetic process; innate immune response; follicular B cell differentiation; blood coagulation

Disease: Autoinflammation, Antibody Deficiency, And Immune Dysregulation, Plcg2-associated; Familial Cold Autoinflammatory Syndrome 3

NCBI Summary:The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]
UniProt Code:P16885
NCBI GenInfo Identifier:215274231
NCBI Gene ID:5336
NCBI Accession:P16885.4
UniProt Secondary Accession:P16885,Q3ZTS2, Q59H45, Q969T5, D3DUL3,
UniProt Related Accession:P16885
Molecular Weight:1265
NCBI Full Name:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
NCBI Synonym Full Names:phospholipase C, gamma 2 (phosphatidylinositol-specific)
NCBI Official Symbol:PLCG2  
NCBI Official Synonym Symbols:FCAS3; APLAID; PLC-IV; PLC-gamma-2  
NCBI Protein Information:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; phospholipase C-IV; phosphoinositide phospholipase C-gamma-2
UniProt Protein Name:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
UniProt Synonym Protein Names:Phosphoinositide phospholipase C-gamma-2; Phospholipase C-IV; PLC-IV; Phospholipase C-gamma-2; PLC-gamma-2
Protein Family:1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
UniProt Gene Name:PLCG2  
UniProt Entry Name:PLCG2_HUMAN
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