Anti-Phospho-MST1/STK4-T387 Antibody (CABP0906)

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SKU:
CABP0906
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
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Description

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抗体名:Anti-Phospho-MST1/STK4-T387 Antibody
抗体コード:CABP0906
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A phospho specific peptide corresponding to residues surrounding T387 of human MST1/STK4.
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:NIH/3T3, C6
免疫原:A phospho specific peptide corresponding to residues surrounding T387 of human MST1/STK4.
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:6789
Uniprot:Q13043
セルラーロケーション:Cytoplasm, Nucleus
計算された分子量:59kDa
観察された分子量:59kDa
Anti-Phospho-MST1/STK4-T387 Antibody (CABP0906)Western blot - Phospho-MST1/STK4-T387 Rabbit pAb (CABP0906)
同義語:KRS2, MST1, YSK3, STK4
バックグラウンド:The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
UniProt Protein Function:Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.
NCBI Summary:The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
UniProt Code:Q13043
NCBI GenInfo Identifier:13124559
NCBI Gene ID:6789
NCBI Accession:Q13043.2
UniProt Secondary Accession:Q13043,Q15802, Q4G156, Q5H982, Q6PD60, Q9BR32, Q9NTZ4 B2RCR8,
UniProt Related Accession:Q13043
Molecular Weight:52,335 Da
NCBI Full Name:Serine/threonine-protein kinase 4
NCBI Synonym Full Names:serine/threonine kinase 4
NCBI Official Symbol:STK4  
NCBI Official Synonym Symbols:KRS2; MST1; YSK3  
NCBI Protein Information:serine/threonine-protein kinase 4
UniProt Protein Name:Serine/threonine-protein kinase 4
UniProt Synonym Protein Names:Mammalian STE20-like protein kinase 1; MST-1
Protein Family:Serine/threonine-protein kinase
UniProt Gene Name:STK4  
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