Anti-Phospho-I?Balpha-S32/S36 Antibody (CABP1201)

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SKU:
CABP1201
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IKBA
Synonyms:
MAD-3
Synonyms:
NFKBI
Synonyms:
IKB alpha
Synonyms:
NFKBIA
Synonyms:
EDAID2
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Description

抗体名:Phospho-I?B?-S32/S36 pAb Rabbit pAb
抗体コード:CABP1201
サイズ:20uL, 50uL, 100uL
同義語:IKBA, MAD-3, NFKBI, IKB alpha, NFKBIA, EDAID2
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:A synthetic phosphorylated peptide around S32/S36 of human I?B?.
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:HeLa
免疫原:A synthetic phosphorylated peptide around S32/S36 of human I?B?.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:4792
Uniprot:P25963
セルラーロケーション:Cytoplasm, Nucleus
計算された分子量:35kDa
観察された分子量:40KDa
UniProt Protein Function:Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
NCBI Summary:This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
UniProt Code:P25963
NCBI GenInfo Identifier:126682
NCBI Gene ID:4792
NCBI Accession:P25963.1
UniProt Secondary Accession:P25963,B2R8L6,
UniProt Related Accession:P25963
Molecular Weight:35,609 Da
NCBI Full Name:NF-kappa-B inhibitor alpha
NCBI Synonym Full Names:NFKB inhibitor alpha
NCBI Official Symbol:NFKBIA  
NCBI Official Synonym Symbols:IKBA; MAD-3; NFKBI  
NCBI Protein Information:NF-kappa-B inhibitor alpha
UniProt Protein Name:NF-kappa-B inhibitor alpha
UniProt Synonym Protein Names:I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
Protein Family:NF-kappa-B inhibitor
UniProt Gene Name:NFKBIA  
UniProt Entry Name:IKBA_HUMAN
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