Anti-Phospho-DPYSL2-T514 pAb Antibody (CABP0821)

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SKU:
CABP0821
Product type:
Antibody
Application:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
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Description

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抗体名:Anti-Phospho-DPYSL2-T514 Antibody
抗体コード:CABP0821
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A phospho specific peptide corresponding to residues surrounding T514 of human DPYSL2
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:SH-SY5Y, PC-12
免疫原:A phospho specific peptide corresponding to residues surrounding T514 of human DPYSL2
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:1808
Uniprot:Q16555
セルラーロケーション:Cytoplasm, Membrane, cytoskeleton, cytosol
計算された分子量:58kDa/62kDa
観察された分子量:69kDa
Anti-Phospho-DPYSL2-T514 pAb (CABP0821)Western blot analysis of extracts of various cell lines, using Phospho-DPYSL2-T514 antibody (CABP0821) at 1:1000 dilution or DPYSL2 antibody (CAB14570). SH-SY5Y cells were treated by CIP(20uL/400ul) at 37'C for 1 hour. PC-12 cells were treated by CIP(20uL/400ul) at 37'C for 1 hour. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
同義語:DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
バックグラウンド:This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:CRMP-2: a microtubule-binding protein necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Homotetramer, and heterotetramer with CRMP1, CRMP-3, CRMP-4, or CRMP-5. Interacts through its C-terminus with the C-terminus of CYFIP1. Interacts with 5-hydroxytryptamine receptor 4 (5-HT(4)).
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Microtubule-binding

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: microtubule; growth cone; mitochondrion; membrane; cell soma; dendrite; terminal button; cytosol

Molecular Function:protein binding; dihydropyrimidinase activity; protein kinase binding

Biological Process: response to drug; axon guidance; nervous system development; olfactory bulb development; response to amphetamine; synaptic vesicle transport; positive regulation of glutamate secretion; cytoskeleton organization and biogenesis; endocytosis; signal transduction; response to cocaine; pyrimidine base catabolic process; spinal cord development; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

NCBI Summary:This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q16555
NCBI GenInfo Identifier:3122051
NCBI Gene ID:1808
NCBI Accession:Q16555.1
UniProt Secondary Accession:Q16555,O00424, A8K5H2, B4DR31, D3DSS7,
UniProt Related Accession:Q16555
Molecular Weight:
NCBI Full Name:Dihydropyrimidinase-related protein 2
NCBI Synonym Full Names:dihydropyrimidinase-like 2
NCBI Official Symbol:DPYSL2  
NCBI Official Synonym Symbols:DRP2; N2A3; CRMP2; DRP-2; ULIP2; CRMP-2; DHPRP2; ULIP-2  
NCBI Protein Information:dihydropyrimidinase-related protein 2; collapsin response mediator protein hCRMP-2; unc-33-like phosphoprotein 2
UniProt Protein Name:Dihydropyrimidinase-related protein 2
UniProt Synonym Protein Names:Collapsin response mediator protein 2; CRMP-2; N2A3; Unc-33-like phosphoprotein 2; ULIP-2
Protein Family:Dihydropyrimidinase-related protein
UniProt Gene Name:DPYSL2  
UniProt Entry Name:DPYL2_HUMAN
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