Anti-EPHB6 抗体 (CAB14729)

抗体名:	Anti-EPHB6 Antibody
抗体コード:	CAB14729
抗体サイズ:	20uL, 50uL, 100uL
申し込み:	WB
反応性:	Human, Mouse, Rat
宿主種:	Rabbit
免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 615-729 of human EPHB6 (NP_001267724.2).

申し込み:	WB
推奨希釈:	WB 1:500 - 1:2000
反応性:	Human, Mouse, Rat
ポジティブサンプル:	Mouse thymus, Mouse brain, Rat brain

免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 615-729 of human EPHB6 (NP_001267724.2).
精製方法:	Affinity purification
ストレージバッファ:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:	IgG
順序:	HFDQ LVAA FDKM IRKP DTLQ AGGD PGER PSQA LLTP VALD FPCL DSPQ AWLS AIGL ECYQ DNFS KFGL CTFS DVAQ LSLE DLPA LGIT LAGH QKKL LHHI QLLQ QHLR QQGS VEV
遺伝子ID:	2051
Uniprot:	O15197
セルラーロケーション:	Membrane, Secreted, Single-pass type I membrane protein
計算された分子量:	57kDa/81kDa/110kDa
観察された分子量:	111kDa

同義語:

EPHB6, HEP

バックグラウンド:

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	EphB6: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; Eph family Chromosomal Location of Human Ortholog: 7q33-q35 Cellular Component: cytosol; extracellular region; plasma membrane Molecular Function:receptor activity Biological Process: ephrin receptor signaling pathway
NCBI Summary:	This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
UniProt Code:	O15197
NCBI GenInfo Identifier:	294862532
NCBI Gene ID:	2051
NCBI Accession:	O15197.4
UniProt Secondary Accession:	O15197,Q2TB23, Q2TB24, A4D2I7, A8CDT5, D3DXD3,
UniProt Related Accession:	O15197
Molecular Weight:	57,498 Da
NCBI Full Name:	Ephrin type-B receptor 6
NCBI Synonym Full Names:	EPH receptor B6
NCBI Official Symbol:	EPHB6
NCBI Official Synonym Symbols:	HEP
NCBI Protein Information:	ephrin type-B receptor 6
UniProt Protein Name:	Ephrin type-B receptor 6
UniProt Synonym Protein Names:	HEP; Tyrosine-protein kinase-defective receptor EPH-6
Protein Family:	Ephrin type-B receptor
UniProt Gene Name:	EPHB6
UniProt Entry Name:	EPHB6_HUMAN

Western blot analysis of extracts of various cell lines, using EPHB6 antibody (CAB14729) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

Antibodies	ELISA Kits
Anti-EPHB6 Antibody (CAB14728)	EPHB6 Colorimetric Cell-Based ELISA Kit
EPHB6 Antibody (PACO00765)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)